In contrast to being overfed and inflamed, becoming metabolically efficient (through low-carbohydrate eating in general, and especially through Intermittent Fasting and nutritional ketosis) optimized autophagy, the natural cellular detoxification process whereby cellular material is recycled, repaired, or destroyed (autophagy means ‘self-eating’). ... Fasting and ketogenic eating are especially helpful to promote autophagy in the brain, and this protective against today’s increasingly common conditions of cognitive decline and disease.