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Fat for Fuel

A Revolutionary Diet to Combat Cancer, Boost Brain Power, and Increase Your Energy

by Dr. Joseph Mercola

|Hay House, INC.©2017·368 pages

Dr. Mercola is a super-popular alternative health physician who runs the equally popular site Mercola.com. In this book, we get a look at his “Mitochondrial Metabolic Therapy” program. MMT for short. As you could probably guess, this is a high-fat (+ “adequate” protein + low-carb) diet. If that approach fires you up, I think you’ll love the book. If not, well… :) Big Ideas we explore include: meeting our mitochondria (the key to health), why “adequate” protein is where it’s at (not low or moderate or high but “adequate”!), mTOR (the cancer switch), good fats (vs. bad ones), peak fasting, and how to win the urge war.


Big Ideas

“My goal in writing this book is to present you with a clear, simple, and rational explanation based on science that will help you understand how your body works at the biological and molecular level. I will also tell you what foods to eat, practical strategies to follow, and ways to monitor your progress to help your mitochondria thrive—a program I call Mitochondrial Metabolic Therapy (MMT).

Simply put, MMT is a system of eating that will help shift your metabolism from burning glucose as your primary fuel to burning fat to fuel your body. When you make this shift, you optimize your mitochondrial function and protect your mitochondrial DNA from potential damage that could lead to disease.

At its most basic level, MMT is a high-fat, adequate-protein, low-carb diet that is built on eating the highest-quality foods available. It is quite a shift from the typical American diet—which is notorious for its excessive grains, sugars, and low-quality fats. …

Please understand that mitochondrial and metabolic health is an emerging discipline and only a handful of researchers and even fewer practicing physicians are actively involved in its study. But I firmly believe that at some point in the near future, metabolic therapy will be accepted as the standard of care not only for cancer but for most chronic diseases.”

~ Dr. Joseph Mercola from Fat for Fuel

Dr. Mercola is a super-popular alternative health physician who runs the equally popular site Mercola.com.

This is the second book of his we’ve featured. Check out the Notes on Effortless Healing as well.

These days, when I do a Note on Nutrition, I feel like I should make a disclaimer. I’m not attached to any one particular view. I am, however, fascinated by the emerging science and willing to make my body/life a laboratory to test what I think makes sense.

Over the last 15+ years, I’ve tested everything from being a fruitarian for a month (yes, it’s true—not quite sure what I was thinking for that month a couple decades ago—lol) to being a low-fat vegan to Paleo to a current approach that centers on a ton of greens/veggies + high-quality fat + “adequate protein” (love that phrase—we’ll talk about it more) and a lower carb approach (no grains, very little fruit and some sweet potatoes, etc.) with almost no sugar and/or refined foods. Oh, and a Plant Paradoxinspired no-lectins.

If you’re interested in a (currently) cutting-edge ketonic approach I think you’ll love the book. (Get a copy here.) If you aren’t, I don’t think you will. (Laughing.)

Of course, the book is packed with Big Ideas and I’m excited to share a few of my favorites with an emphasis on the Ideas that I’m currently testing in the lab that is my life. So… Let’s jump in!

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In recent years, scientists have come to realize that it’s not genetic mutations that cause cancer. We now know that mitochondrial damage happens first.
Dr. Joseph Mercola
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Meet Your Mitochondria

“Perhaps you recall hearing about mitochondria in your high school biology class or have read about mitochondrial disease on the Internet, but you are still not quite sure what mitochondria are or what function they serve. Mitochondria are so vital to your health that if you are interested in warding off and healing from disease, it is critical for you to learn more about them.

Mitochondria are tiny organelles (think of them as micro-organs) contained within nearly all your cells. One of their many critical roles is to produce energy by combining nutrients from the sugars and fats you eat with oxygen from the air you breathe.

Researchers estimate that mitochondria account for 10 percent of your body weight, with approximately 10 million billion within the cells of an average adult. If that number is hard to comprehend, consider that more than 1 billion mitochondria would fit on the head of a pin.”

Dr. Mercola’s approach is called “Mitochondrial Metabolic Therapy” or “MMT.”

He kicks the book off with a high-level overview of mitochondria and why they’re so important. We talked about the importance of mitochondria in Head Strong and Power Up Your Brainas well. In Head Strong, Dave Asprey says:Your mitochondria determine how your body reacts to the world around you. When your mitochondria become more efficient, your mental performance increases. The better your mitochondria are at creating energy, the better your body and mind will perform, the more you can do, and the better you will feel while doing it.”

So, your mitochondria are super important. They’re the little power centers inside every cell. It’s the breakdown of our MITOCHONDRIA that initiates disease. Therefore, we want to make sure we’re taking good care of them.

And, I’m still blown away by just how many of them we have in our bodies.

10,000,000 x 1,000,000,000 = 10,000,000,000,000,000.

That’s a lot of zeroes. 16, in fact. Over a QUADRILLION mitochondria organelles in our body. 1 billion of which can, apparently, fit on the head of a pin yet, when they’re all thrown together in that body that is you, they make up 10% of your total body weight. Mind-bendingly awesome. Now, let’s take a look at how to make them happy.

What all this means is that when you remove processed foods, sugar, grains, and high-net-carb fuels from your diet, you essentially stress cancer cells by depriving them of their preferred metabolic food.
Dr. Joseph Mercola

“Adequate” protein

“For 60 years the gold standard in preserving health, extending life, and slowing down the aging process in animal studies has been calorie restriction, where you simply lower your caloric intake while still eating enough to prevent malnutrition. Calorie restriction is known to alter the expression of hundreds to thousands of genes. Some of these are related to longevity and some play a role in metabolism, cell growth, reproduction, immune response, and other important biological processes. These effects have been observed in a variety of species from worms and yeast to rats and fish, and there’s strong evidence that suggests calorie restriction has a similar effect on the human life span as well.

Despite its simplicity and proven merit, calorie restriction remains a strategy few people are willing to embrace. The good news is that eating a high-fat adequate-protein, and low-carb diet allows you to reap the benefits of calorie restriction without deprivation or difficulty.

The research community has recently begun to tease out that it’s not a lack of total calories that triggers the beneficial effects of energy-restricted diets. Instead, the latest science suggests that this phenomenon may actually result more from reduced protein intake—specifically the reduced intake of the amino acid methionine, high levels of which are found in meats. To be clear, you do not want to eliminate methionine entirely, as methionine is a methyl donor for one of the most important antioxidants you have, glutathione. You just need to lower it.”

Focal point here: “ADEQUATE protein.”

Not “high.” Not “low.” Not “moderate.”

ADEQUATE.

As in, basically, just enough to meet your needs.

This concept and reintroducing intermittent fasting (which we’ll talk about in a moment) are the two Big Ideas that I’ve experimented with the most as a direct result of this book.

Dr. Gundry recommends the same “adequate protein” approach in The Plant Paradox. He suggests four ounces of animal protein per day—which is what I’m currently experimenting with.

My health/fitness/nutrition coach, the super-fit Ben Greenfield is all about the lower protein approach as well.

As is Mark Hyman. In Eat Fat, Get Thin he tells us to go “pegan”—combining the best of both the vegan and Paleo worlds. Specifically, he says: “I focus specifically on the cross-section of vegan and Paleo because the middle ground between these two approaches is the most doable, sensible, sustainable, delicious, healthful, and science-based way of eating.”

He also makes the point that a HIGH-FAT vegan diet outperforms the low-fat approach: “A study of any diet of whole foods—vegan or Paleo—will do far better than the awful processed industrial diet. But what happens when you compare two whole-food, good-quality vegan diets—one low-fat and one high-fat? This has been done, and the high-fat, high-protein, low-carb, low- glycemic vegan diet (Eco-Atkins) performed better for weight loss and lowering cholesterol than the low-fat vegan diet that avoided nuts, seeds, and avocados.”

Having said that, I like this thought the most as it relates to experimenting and figuring out what works for YOU: “LeBron James, considered one of the greatest basketball players of our time, follows a Paleo diet. The number one tennis player in the world, Novak Djokovic, cut out gluten and dairy and ate a higher-fat diet and went from losing match after match to winning every major tennis tournament in a year. Rich Roll completed five Ironman triathlons in seven days on a high-fat vegan diet. Humans are amazingly adaptable. But the only important question is, What is the right diet for the human that matters most—you?”

P.S. Important note: Of course, when I was vegan, I cut out ALL animal protein. My current take on the research along with a number of discussions with highly-respected functional medicine doctors (and my own experimenting) is that SOME animal protein is important.

Of course, there are very strong moral considerations that influence many people’s decisions on this—which, of course, I admire and respect.

Again, as always, there is no THE way. We each need to discover OUR way.

Thank you, Fred: “‘This is my way; where is yours?’—Thus I answered those who asked me ‘the way.’ For the way— that does not exist.”

Fortunately, the key to slowing down the aging process is already in your hand—you simply need to stop eating more protein than your body requires for tissue repair. Reducing protein intake is so effective that it will likely become an even more visible component of anticancer and anti-aging dietary interventions in the future.
Dr. Joseph Mercola

mTOR: Flip the Cancer switch off

“Of all the nutrients that stimulate mTOR, amino acids—which are derived from protein—are the most potent. Stimulating mTOR by eating large amounts of protein is also one of the quickest ways to suppress cellular and mitochondrial autophagy, which prevents your body from effectively cleaning out debris and damaged cells. Even if you are optimizing everything you can to keep glucose and insulin levels low, eating excessive protein will still activate the mTOR pathway. If your goal is to treat disease and live long, doing this chronically is something you want to avoid.

Virtually all cancers are associated with mTOR activation, and inhibiting mTOR with drugs, such as rapamycin, for which mTOR is named, is a common and highly effective anticancer treatment. This is why Rosedale and I now believe that protein restriction may be even more important than the restriction of net carbohydrates (total carbs minus fiber) from your diet.”

That (+ the prior Idea) are from a chapter called “The Protein Paradox” in which Mercola walks us through the fact that, although essential for our health, too much protein is not a good thing.

Why? Well, one of the reasons is that excessive protein activates what’s know as “mTOR” which is short for the “Mammalian (or Mechanistic) Target of Rapamycin.”

As Mercola says: “When mTOR is not stimulated, it instructs the cell to turn on the array of repair and maintenance processes at its disposal, including autophagy (cleaning up cellular debris), DNA repair, and activating intracellular antioxidants and heat-shock proteins (HSPs). When it is activated, it cues the cell to grow and proliferate; it also suppresses most cellular and mitochondrial repair and regeneration mechanisms.”

It’s interesting because as I typed that I thought of our Peak Performance growth equation. Recall: Stress + Rest = Growth.

Protein is a great builder. A “good stress” in the building process if you will. But, we can’t have that switch flipped ON all the time. We need to flip it OFF and allow for the recovery. THAT’s when the sustainable, healthy growth occurs. More accurately, during that “rest” phase is when autophagy occurs—when our body gets to press pause on all the building and take out the trash, cleaning up “cellular debris” to keep our cells nice and shiny and happy.

So… Question: How’s your protein intake?

P.S. Wondering what “adequate” protein means? Here’s a blog post by Mercola that addresses that question. Short story: “This formula calls for about 0.5 gram of protein per pound of lean body mass (or for the Europeans: 1 gram per kg of lean body mass). Pregnant women and those who are aggressively exercising or competing should have about 25 percent more.

To determine your lean body mass, simply subtract your percent body fat from 100. For example, if you have 20 percent body fat, then you have 80 percent lean body mass. Just multiply that percentage (in this case, 0.8) by your current weight to get your lean body mass in pounds or kilos. In the above example, if you weighed 160 pounds, 0.8 multiplied by 160 equals 128 pounds of lean body mass. Using the ‘0.5 gram of protein’ rule, you would need about 64 grams of protein per day.”

In simple terms, when you eat carbohydrates, your pancreas secretes insulin. And the more insulin you have in your blood, the more signals your body gets to store fat. In other words, by following the present dietary advice that was officially codified by the government in 1977, we as a nation have been doing the very things that cause us to gain weight and keep it on.
Dr. Joseph Mercola

Fats: Go with the good ones

“There are no two ways about it: MMT is a high-fat diet. To promote your shift to fat burning, you want to get the majority of your calories from fat. But you must choose your fats wisely.

It’s imperative that you choose healthy fats (which I’ll go over in just a moment) and eliminate all industrially processed fats—including vegetable oils such as canola, peanut, cottonseed, corn, and soy—as well as all trans fats, such as those found in commercial salad dressings, peanut butter, most mayonnaise, and anything processed or packaged. It’s important that you read the ingredients, not just the label: if you see ‘hydrogenated fats’ listed in the ingredients, that food contains trans fats, even if they’re at a level below what needs to be reported on the label.

As I covered in detail, refined oils are deadly for a wide variety of reasons: they throw your omega-6 to omega-3 ratios out of balance, they are highly susceptible to oxidation (which kicks off a storm of free radical damage within your mitochondria), they carry high levels of pesticides because most vegetable oils are extracted from genetically modified glyphosate-soaked plants, and they become even more volatile and harmful when they are subjected to heat.

If you decided to personally adopt MMT, which I sincerely hope you will do, but you replace your current high-carb calories with calories from industrially processed fats, you will not enjoy any benefits from this diet. Instead, you’ll be creating even more harm to your mitochondria and overall health.”

That’s from the chapter “What to Eat on MMT: The Cleanest, Most Efficient Fuel for Your Body.” First, know that if you’re going to follow MMT and add a lot of fats, you must a) simultaneously reduce your carbs and b) make sure your fats are a high quality.

The good fats? Mercola loves coconut oil and MCT oil. And avocados (“one of the healthiest foods you can eat”; he eats one to three per day). And olives (“a wonder of nature”) and olive oil (which Mark Hyman calls “liquid gold”).

What needs to go? Well, let’s walk over to your pantry and give ALL your veggie oils a boot: canola oil? Gone. Soy, corn, sunflower, safflower, peanut, and cottonseed? Trash can.

I know “vegetable” oils sound so nutritious but they’re NOT. They didn’t exist before the turn of the 20th century and anything that recently added to our food supply should be limited.

(btw: Did you know that Americans consume 18 BILLION pounds of soybean oil per year? An ASTONISHING 20% of our calories come from soybean oil alone. TWENTY PERCENT!!)

Sugar fans the flames of inflammation in your body, as it is a dirty fuel that was never intended to be our primary fuel. Using sugar for energy produces 30 to 40 percent more ROS [reactive oxygen species] than burning fat.
Dr. Joseph Mercola

Intermittent Fasting: Peak Fasting

“As a general rule I recommend a specific type of intermittent fasting that I call Peak Fasting. This is my hands-down favorite form of fasting and the one I personally use. It is by far the easiest to maintain once your body has shifted over from burning sugar to burning fat as its primary fuel, and it also appears to support steady circadian rhythms. …

The crux of Peak Fasting is to restrict your eating each day to a 6- to 11-hour window. As a result, you will avoid eating for 13 to 18 hours of every day. The simplest way to implement Peak Fasting is to stop eating at least three hours before bed, and then delay your first meal of the following day until at least 13 hours have passed since you last ate. …

This may seem like an awfully long time to go without eating on a daily basis, but once you have transitioned to burning fat as your primary source of fuel, you won’t experience those frequent hunger pangs. Another benefit of Peak Fasting is that you will be able to go for hours without a dip in energy because fat provides a continuous source of fuel. This is in contrast to glucose, which triggers glucose/insulin spikes, frequent hunger pangs, and energy crashes as cues to consume more high-carb foods.”

That’s from a chapter called “The Power of Fasting to Optimize Mitochondrial Health” in which Mercola walks us through the array of fasting techniques that have been shown to help us Optimize—from 2 day water fasts to his favorite: Peak Fasting.

This is what I currently do. Last meal around sunset, next meal at least 14 or so hours later. Often 16-18 hours later. It’s super easy. Energy is nice and stable. Note: There’s NO WAY I could have done that when I ate a ton of grains. I was, as David Ludwig says, “Always Hungry!”

Why is this so good? Remember the autophagy/cell clean up? When we fast, the crews get to work. Keeping our cells nice and shiny and happy!

btw: Mercola is also all about limiting food before sleep. He says: “I believe one of the best strategies for reducing mitochondrial free radical production is to limit the amount of fuel you feed your body when it requires the least amount, which is when you are sleeping. That’s why I stop eating four to six hours before I go to bed, although a three-hour window is also beneficial and probably more doable for most people.”

Note to self: Stop eating even earlier before bedtime!

P.S. IMPORTANT NOTE from Mercola: “Although I believe intermittent fasting, particularly Peak Fasting, is a powerful way to improve your physiological function all the way down to the mitochondrial level, it is not for everyone. Individuals taking medications, especially diabetics, need medical supervision; otherwise there is a risk of hypoglycemia.”

Winning the Urge War

“It is so much easier to resist the urge to eat carbs if they aren’t in your home. An essential part of your preparation for adopting MMT is going through your pantry and cupboards and removing anything that is not compatible with the plan. Give it away to friends, or take it to a food bank. You may even be able to return unopened packaged foods to your grocery store and use the money you get back to purchase foods that are MMT friendly. The more quickly you work through this step, the less likely it is that you’ll run into temptation.”

Whether you follow a Mercola-inspired MMT diet or a vegan or a Paleo or some modification of whatever approach you like, you probably consume some stuff that you know is sub-optimal.

Best way to eliminate it? Go to your pantry once more. Throw away/donate the stuff that needs to go. Then, most importantly, QUIT BUYING IT. Buy your willpower at the store. Play offense rather than defense. And, Optimize.

So… On that note, what’s one thing that you know needs to go?

Here’s to fueling those quadrillion+ mitochondria like the world-champion version of you!

About the author

Dr. Joseph Mercola
Author

Dr. Joseph Mercola

Osteopathic physician and health activist.